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KMID : 0350519940470020811
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Journal of Catholic Medical College
1994 Volume.47 No. 2 p.811 ~ p.821
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Expression of Epidermal Growth Factor Receptor Detected by In Situ mRNA Hybridization in Breast Cancers and its Prognostic Significance
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Abstract
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Recent studies have demonstrated that epidermal growth factor(EGF) and its receptor(EGFR) play an important role for the carcinogenesis and progression of various malignant tumors including breast cancer. In human breast cancer, the expression of
EGFR
was suggested as an independent prognostic factor, and an inverse relationship between the expression of EGFR and estrogen receptor(ER) by several investigators. Therefore, the expression of EGFR may be important not only for the
normone-independent
tumor growth, but also for predicting poor prognosis.
In this study we investigated the correlation between the expression of EGFR by EGFR-mRNA in situ hybridization method and tumor size, lymph node status and ER status, and its relation to overall and relapse-free survival in breast cancer in
Korean
women.
@ES The results were as followed:
@EN 1. Thirty out of fifty six(53.6%) cases were showed the expression of EGFR.
2. Lymph node status(P=0.0004), ER(P=0.0044) and EGFR status(P=0.0209) were the powerful prognostic predictors on overall survival and lymph node status(P=0.0451) on relapse-free survival.
3. No significant relationship was found between the expression of EGFR and age, tumor size, nodal status, clinical stage and ER status.
4. There was inverse trend between the expression of EGFR and of ER, but statistically not significant. ER negative-EGFR positive cancers had the lowest 5 year survival(26.3±0.1%, P=0.0232) and the shortest relapse-free survival (38.2±6.7
months,
statistically not significant) among those of other ER-EGFR status.
These results suggest that EGFR status may be important for the prediction of prognosis. And the patients with ER negative-EGFR positive breast cancer should be considered as a new subject which need aggressive postoperative therapeutic
modalities.
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KEYWORD
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